Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis.

Product information

CAS Number: 59450-89-4

Molecular Weight: 542.65

Formula: C58H72CaN6O12

Chemical Name: calcium 5-(methylamino)-2-(((2R, 3R, 6S, 8S, 9R, 11R)-3, 9, 11-trimethyl-8-((S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl)-1, 7-dioxaspiro[5.5]undecan-2-yl)methyl)benzo[d]oxazole-4-carboxylate

Smiles: [Ca+2].C[C@@H]1CC[C@]2(O[C@@H]1CC1=NC3=C(C(=CC=C3O1)NC)C([O-])=O)O[C@H]([C@H](C)C(=O)C1=CC=CN1)[C@H](C)C[C@H]2C.C[C@@H]1CC[C@]2(O[C@@H]1CC1=NC3=C(C(=CC=C3O1)NC)C([O-])=O)O[C@H]([C@H](C)C(=O)C1=CC=CN1)[C@H](C)C[C@H]2C

InChiKey: LAQWEYASNNRUGY-UIOMRPQBSA-L

InChi: InChI=1S/2C29H37N3O6.Ca/c2*1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;/h2*6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);/q;;+2/p-2/t2*15-,16-,17-,18-,22-,27+,29+;/m11./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Calcimycin hemicalcium salt (A-23187 calcium) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.

In Vivo:

Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage.

Products are for research use only. Not for human use.