ADAM10 Polyclonal Antibody

Product: 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16999-50, BZ16999-100

Swiss-Prot: O14672

Host: Rabbit

Reactivity: Human

Applications: WB, IP

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Calculated MW: 84 kDa; Observed MW: 90,68 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of ADAM10 in NTERA-2 lysates using ADAM10 antibody.

Alternative Name: CDw156; CD156c; ADAM10; KUZ; MADM

Immunogen: A synthetic peptide of human ADAM10

Conjugate: Unconjugated

Modification: Unmodified