SCAP Monoclonal Antibody

Catalogue Numbers: MB67084-50, MB67084-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q12770

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/1000 - 1/2000)

Background: SREBP cleavage activating protein (SCAP) is a membrane-bound protein essential in regulating sterol regulatory element binding protein (SREBP) processing. In cholesterol-starved cells, SREBPs move from the ER to the Golgi apparatus with the help of SCAP, where the precursor SREBPs are cleaved by site-1 (S1P) and site-2 (S2P) proteases. Released SREBP amino-terminal domains enter the nucleus and bind to sterol response elements located in the promoters of a number of genes responsible for the cholesterol synthesis. Research studies show that the SCAP/SREBP pathway is critical for diabetic fatty liver development and carbohydrate-induced hypertriglyceridemia in mice. In addition, the SCAP/SREBP pathway is required to protect cancer cells from lipotoxicity.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of SCAP protein.

Extra Notes: Western blot analysis of SCAP expression in HT29 (A), LNCaP (B) whole cell lysates.

Bioworld Molecular Weight: ~ 115 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: KIAA0199; Sterol regulatory element-binding protein cleavage-activating protein; SCAP; SREBP cleavage-activating protein

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human SCAP. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified