Ret Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA29355-50, RA29355-100

Citations, Manuals and MSDS Available upon request.

Background: ret proto-oncogene (RET) Homo sapiens This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000

Alternative Names: Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1;Cadherin family member 12;Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]

Applications: WB; IHC-p; IF (paraffin section) ; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 5979

Protein MW (KDa): 124

SWISS: P07949

Source: Rabbit

Research Use Only