MtTMPK-IN-8 (compound 27) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor. MtTMPK-IN-8 has sub-micromolar activity against mycobacteria (MICs = 0.78~9.4 μM) without significant cytotoxicity. MtTMPK-IN-8 can be used for researching tuberculosis[1].

Product information

Molecular Weight: 508.48

Formula: C24H24N6O7

Chemical Name: N-({4-[4-(5-methyl-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidin-1-yl)piperidin-1-yl]phenyl}methyl)-3, 5-dinitrobenzamide

Smiles: CC1=CN(C2CCN(CC2)C2C=CC(CNC(=O)C3C=C(C=C(C=3)[N+]([O-])=O)[N+]([O-])=O)=CC=2)C(=O)NC1=O

InChiKey: ZDMGZOOCIIYGOI-UHFFFAOYSA-N

InChi: InChI=1S/C24H24N6O7/c1-15-14-28(24(33)26-22(15)31)19-6-8-27(9-7-19)18-4-2-16(3-5-18)13-25-23(32)17-10-20(29(34)35)12-21(11-17)30(36)37/h2-5,10-12,14,19H,6-9,13H2,1H3,(H,25,32)(H,26,31,33)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Jian Y, et al. Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur J Med Chem. 2020;206:112659.

Products are for research use only. Not for human use.