DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application.

Product information

CAS Number: 2375846-41-4

Molecular Weight: 458.50

Formula: C25H28F2N2O4

Chemical Name: 2-{[(tert-butylcarbamoyl)(4-fluorophenyl)methyl](methyl)amino}ethyl (2E)-4-(4-fluorophenyl)-4-oxobut-2-enoate

Smiles: CN(CCOC(=O)/C=C/C(=O)C1C=CC(F)=CC=1)C(C1C=CC(F)=CC=1)C(=O)NC(C)(C)C

InChiKey: RJGWWNVHLMPYEN-BUHFOSPRSA-N

InChi: InChI=1S/C25H28F2N2O4/c1-25(2,3)28-24(32)23(18-7-11-20(27)12-8-18)29(4)15-16-33-22(31)14-13-21(30)17-5-9-19(26)10-6-17/h5-14,23H,15-16H2,1-4H3,(H,28,32)/b14-13+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs with IC50s of 10.99 μM, 9.70 μM, 8.30 μM, 55.71 μM, respectively.

Products are for research use only. Not for human use.