PDI Monoclonal Antibody

Catalogue Numbers: MB66820-50, MB66820-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P07237

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/1000 - 1/2000)

Background: Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer consisting of subunits that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDI localizes to the lumen of the endoplasmic reticulum (ER), where in conjunction with folding-helper proteins, such as immunoglobulin heavy chain binding protein (BiP), it mediates tertiary and quaternary protein processing. Cell surface PDI induces sulfhydryl-mediated conformational changes in integrin-mediated adhesion receptor-ligand interactions, thereby regulating integrin responses and cell adhesion. Additionally, PDI functions as a subunit of two more complex enzyme systems: the prolyl-4-hydroxylase and the triacylglycerol transfer proteins.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of PDI protein.

Extra Notes: Western blot analysis of PDI expression in Hela (A), MCF7 (B), HepG2 (C), PANC1 (D) whole cell lysates.

Bioworld Molecular Weight: ~ 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: ERBA2L; PDI; PDIA1; PO4DB; Protein disulfide-isomerase; PDI; Cellular thyroid hormone-binding protein; Prolyl 4-hydroxylase subunit beta; p55

Immunogen: Recombinant fusion protein of human PDI. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified