CMKLR1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16428-50, BZ16428-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q99788

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-F, IHC-P, ICC/IF, ELISA

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000

Background: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 42 kDa; Observed MW: 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CMKLR1 in various lysates using CMKLR1 antibody., Western blot analysis of CMKLR1 in COLO205 lysates using ChemR23 antibody., Western blot analysis of CMKLR1 in 293T lysates using ChemR23 antibody., Western blot analysis of CMKLR1 in 293T lysates using CMKLR1 antibody.

Alternative Name: DEZ; RVER1; ChemR23; CHEMERINR

Immunogen: The antiserum was produced against synthesized peptide derived from human CMKLR1. AA range:221-270

Conjugate: Unconjugated

Modification: Unmodified