AMZ30 (ML136, CS-2122) is a selective and covalent inhibitor of protein phosphatase methylesterase-1(PME-1) with IC50 of 0.60 μM. AMZ30 reduces the demethylated form of PP2A in living cells.

Product information

CAS Number: 1313613-09-0

Molecular Weight: 461.44

Formula: C19H12FN3O6S2

Chemical Name: (2E)-2-(4-fluorobenzenesulfonyl)-3-[1-(3-nitrobenzenesulfonyl)-1H-pyrrol-2-yl]prop-2-enenitrile

Smiles: N#C/C(=C\C1=CC=CN1S(=O)(=O)C1=CC(=CC=C1)[N+]([O-])=O)/S(=O)(=O)C1C=CC(F)=CC=1

InChiKey: GUCUORSUHTZMBW-YBFXNURJSA-N

InChi: InChI=1S/C19H12FN3O6S2/c20-14-6-8-17(9-7-14)30(26,27)19(13-21)11-15-4-2-10-22(15)31(28,29)18-5-1-3-16(12-18)23(24)25/h1-12H/b19-11+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.